Recurrent organization could appear starting from just relatively simple sets of chemical aggregates. Focusing on the plausibility of such organized systems through the prebiotic evolution, some conditions should be addressed: (a)Molecularity; (b) Recursive self-maintained; (c) Autopoiesis; (d) Thermodynamic coherence; Stoichiometric coherence; (e) Self-reproduction; and (f) Increase of structural and functional complexity.
In this contribution,we present a discussion on some of these aspects. This is illustrated with different proposed models (Montero, F., et al. 2008, Stoichiometric analysis of self-maintaining metabolisms. J. Theor. Biol. 252:427-32; Olasagasti, F., et al. 2007, Energeticallyplausible model of a self-maintaining protocellular system. Bull. Math. Biol.69, 1423-1445) that represent theoretical metabolic Self-Maintained Systems that satisfies some of the aforementioned questions. With these models we provide a better understanding of how early cells could have developedbefore achieving highly complex tasks such as the synthesis of informational genetic molecules.